Utility values in Japanese patients with exudative age-related macular degeneration

Jpn J Ophthalmol. 2011 Jan;55(1):35-8. doi: 10.1007/s10384-010-0893-y. Epub 2011 Feb 18.


Purpose: To investigate the utility values associated with visual loss due to age-related macular degeneration (AMD) in Japanese patients.

Methods: Utility values in 48 Japanese patients with bilateral exudative AMD were measured using the time trade-off and standard gamble methods.

Results: The time trade-off method utility values correlated with the best-corrected visual acuity (BCVA) in the better-seeing eye. The estimated utility values according to the BCVA in the better-seeing eye were 0.534 (BCVA, 0.01-0.15), 0.574 (0.2-0.3), 0.613 (0.4-0.6), and 0.653 (0.7-1.0). The utility values obtained by the standard gamble method were not significantly correlated with BCVA in the better-seeing eye.

Conclusions: The present results concur with those of previous studies showing that AMD causes a substantial decrease in patient utility values. The utility values obtained in the current study provide important information for use in cost-utility analysis of interventions for Japanese AMD patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Asian Continental Ancestry Group / ethnology
  • Cost-Benefit Analysis
  • Exudates and Transudates
  • Female
  • Functional Laterality
  • Humans
  • Japan / epidemiology
  • Macular Degeneration / ethnology
  • Macular Degeneration / psychology*
  • Male
  • Middle Aged
  • Quality of Life / psychology*
  • Quality-Adjusted Life Years*
  • Sickness Impact Profile
  • Vision Disorders / ethnology
  • Vision Disorders / psychology*
  • Visual Acuity / physiology