Normal tension glaucoma and Alzheimer disease: comorbidity?

Acta Ophthalmol. 2012 Nov;90(7):683-5. doi: 10.1111/j.1755-3768.2011.02125.x. Epub 2011 Feb 18.


Purpose: To investigate whether normal tension glaucoma (NTG) is associated with increased risk of developing dementia/Alzheimer disease (AD).

Methods: A total of 69 patients with NTG were identified in the case note files in the Glaucoma Clinic, University Hospital of Copenhagen (Rigshospitalet), Denmark from 1980 to 2001. The rate of a subsequent diagnosis of dementia as recorded in nationwide health care registers from 1980 to 2005 was estimated and compared with the rate for the general population [standard mortality rate (SMR) = observed number of cases of dementia/expected number of cases of dementia].

Results: The 69 patients had a median age of 64 years (quartiles 57 and 73) at the time of the diagnosis, and the average follow-up period was 12.7 years. The SMR(dementia) was 0.20 (95% CI 0.01-1.11). No patient developed AD.

Conclusion: Normal tension glaucoma was not associated with an increased risk of developing dementia/AD.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / diagnosis
  • Alzheimer Disease / epidemiology*
  • Antihypertensive Agents / therapeutic use
  • Ciliary Body / surgery
  • Comorbidity
  • Denmark / epidemiology
  • Female
  • Humans
  • Intraocular Pressure
  • Laser Coagulation
  • Low Tension Glaucoma / diagnosis
  • Low Tension Glaucoma / epidemiology*
  • Low Tension Glaucoma / therapy
  • Male
  • Middle Aged
  • Registries
  • Risk Factors
  • Trabeculectomy


  • Antihypertensive Agents