Development of 2,4-diaminopyrimidine derivatives as novel SNSR4 antagonists

Bioorg Med Chem Lett. 2011 Apr 1;21(7):2102-5. doi: 10.1016/j.bmcl.2011.01.138. Epub 2011 Feb 3.


2,4-Diaminopyrimidines derivatives were developed as a novel class of SNSR4 antagonists. Structure activity relationship of the diamino pyrimidine core was explored and a tool compound suitable for target validation was identified.

MeSH terms

  • Inhibitory Concentration 50
  • Pyrimidines / pharmacology*
  • Receptors, Cell Surface / antagonists & inhibitors*
  • Sensory Receptor Cells / drug effects*
  • Sensory Receptor Cells / metabolism


  • Pyrimidines
  • Receptors, Cell Surface
  • 2,4-diaminopyrimidine