Guiding blind T cells and dendritic cells: A closer look at fibroblastic reticular cells found within lymph node T zones

Immunol Lett. 2011 Jul;138(1):9-11. doi: 10.1016/j.imlet.2011.02.006. Epub 2011 Feb 17.


It is within the T cell rich zone of secondary lymphoid organs (SLO) that dendritic cells (DC) present the captured pathogens to recirculating T cells in order to activate the rare antigen-specific T cells. While we have made considerable progress in understanding the biology of mobile hematopoietic cells found within SLO, notably DC and lymphocytes, we still have a lot to learn about the sessile stromal cells. This review is focused on the recent progress made in our understanding of the fibroblastic reticular stromal cells that form the 'niches' within the T zone.

Publication types

  • Review

MeSH terms

  • Adaptive Immunity / immunology
  • Animals
  • Connective Tissue Cells / immunology*
  • Dendritic Cells / immunology*
  • Humans
  • Lymph Nodes / immunology*
  • Lymphoid Tissue / cytology
  • Lymphoid Tissue / immunology
  • Stromal Cells / immunology
  • T-Lymphocytes / immunology*