Maintaining a memory by transcriptional autoregulation

Curr Biol. 2011 Feb 22;21(4):R146-7. doi: 10.1016/j.cub.2011.01.005.


One of the key features of cellular differentiation programs is stability. Although differentiation is reversible in principle, many components of the gene batteries induced upon terminal differentiation are maintained throughout a cell's life. For example, muscle cells continuously express the myosin gene, and GABAergic neurons continuously express genes for GABA synthesis and transport. Maintaining gene expression patterns in the nervous system is a particular challenge given the non-renewing nature and therefore extensive life span of many neuronal cell types.

MeSH terms

  • Animals
  • Base Sequence
  • Caenorhabditis elegans / metabolism
  • Caenorhabditis elegans Proteins / genetics
  • Caenorhabditis elegans Proteins / metabolism
  • Cell Differentiation
  • DNA / genetics
  • Gene Expression Regulation / physiology*
  • Mutation
  • Neurons / cytology
  • Neurons / metabolism


  • Caenorhabditis elegans Proteins
  • DNA