Cellular reprogramming: chromatin puts on the brake

Curr Biol. 2011 Feb 22;21(4):R157-9. doi: 10.1016/j.cub.2010.12.044.


Directed reprogramming of differentiated cells allows the generation of specific cell types for therapeutics and can provide unexpected insights into development. A recent study demonstrates that efficient reprogramming of Caenorhabditis elegans germ cells into neurons can be achieved by knocking down a histone chaperone gene and ectopic expression of a terminal selector transcription factor.

MeSH terms

  • Animals
  • Caenorhabditis elegans / cytology*
  • Cell Differentiation
  • Chromatin / physiology*
  • Gene Expression Regulation / physiology
  • Neurons / cytology*
  • Neurons / physiology*
  • Transcription Factors


  • Chromatin
  • Transcription Factors