The Exogenous Opioid Peptides and DPPIV Serum Activity in Infants With Apnoea Expressed as Apparent Life Threatening Events (ALTE)

Neuropeptides. 2011 Jun;45(3):189-95. doi: 10.1016/j.npep.2011.01.005. Epub 2011 Feb 21.


Casein-derived peptides have been suggested to play a role in sudden infant death syndrome (SIDS). In this study, we have determined the content of bovine β-casomorphin-7 (bBCM-7) and the activity of dipeptidyl peptidase-IV (DPPIV) in sera of infants with apparent life threatening events (ALTE syndromes, 'near miss SIDS'). We have found that the sera of some infants after an apnoea event contained more β-casomorphin-7 than that of the healthy infants in the same age. In all the children after an apnoea event, however, a lowered DPPIV was detected. We suspect that the low activity of that peptidase may be responsible for opioid-induced respiratory depression, induced by bBCM-7 in the general circulation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apnea / blood*
  • Cattle
  • Dipeptidyl Peptidase 4 / blood*
  • Endorphins / blood*
  • Humans
  • Infant
  • Opioid Peptides / blood*
  • Peptide Fragments / blood*
  • Sudden Infant Death


  • Endorphins
  • Opioid Peptides
  • Peptide Fragments
  • beta-casomorphin 7
  • Dipeptidyl Peptidase 4