Density of metabotropic glutamate receptors 2 and 3 (mGluR2/3) in the dorsolateral prefrontal cortex does not differ with schizophrenia diagnosis but decreases with age

Schizophr Res. 2011 May;128(1-3):56-60. doi: 10.1016/j.schres.2011.01.008. Epub 2011 Feb 21.


Metabotropic glutamate receptors 2 and 3 (mGluR2/3) have been shown as efficient targets for antipsychotic intervention. We therefore investigated the receptor density of mGluR2/3 in the dorsolateral prefrontal cortex (dlPFC; Brodman area 46) of schizophrenia/schizoaffective patients (n=37) and matched controls (n=37) using receptor autoradiography. No difference in mGluR2/3 density was identified in relation to schizophrenia diagnosis. Overall and in individual groups, a negative correlation of mGluR2/3 density and age at death has been found. These and previous results suggest that density of mGluR2/3 in the dlPFC is less likely to impact on the efficiency of the mGluR2/3 agonist in treating schizophrenia symptoms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aging / metabolism*
  • Aging / pathology
  • Bridged Bicyclo Compounds / pharmacokinetics
  • Excitatory Amino Acid Agonists / pharmacokinetics
  • Female
  • Humans
  • Male
  • Middle Aged
  • Postmortem Changes
  • Prefrontal Cortex / diagnostic imaging*
  • Prefrontal Cortex / drug effects
  • Protein Binding / drug effects
  • Radiography
  • Radioligand Assay
  • Receptors, Metabotropic Glutamate / metabolism*
  • Schizophrenia / pathology*
  • Statistics as Topic
  • Tritium
  • Young Adult


  • Bridged Bicyclo Compounds
  • Excitatory Amino Acid Agonists
  • Receptors, Metabotropic Glutamate
  • metabotropic glutamate receptor 2
  • metabotropic glutamate receptor 3
  • Tritium
  • eglumetad