How Institut Georges Lopez preservation solution protects nonsteatotic and steatotic livers against ischemia-reperfusion injury

M A Zaouali; H Ben Abdennebi; S Padrissa-Altés; I Alfany-Fernandez; A Rimola; J Roselló-Catafau

doi:10.1016/j.transproceed.2010.12.026

How Institut Georges Lopez preservation solution protects nonsteatotic and steatotic livers against ischemia-reperfusion injury

Transplant Proc. 2011 Jan-Feb;43(1):77-9. doi: 10.1016/j.transproceed.2010.12.026.

Authors

M A Zaouali¹, H Ben Abdennebi, S Padrissa-Altés, I Alfany-Fernandez, A Rimola, J Roselló-Catafau

Affiliation

¹ Experimental Hepatic Ischemia-Reperfusion Unit, Institut d'Investigacions Biomèdiques de Barcelona, Consejo Superior de Investigaciones Científicas, Barcelona, Spain.

PMID: 21335159
DOI: 10.1016/j.transproceed.2010.12.026

Abstract

The Institut Georges Lopez preservation solution (IGL-1) is a serum-free organ preservative that has been shown to protect steatotic livers against hepatic ischemia-reperfusion injury. Although several hypotheses have been proposed to explain the graft protection mechanisms induced by IGL-1 solution, they have not been fully investigated. This review assessed possible IGL-1 mechanisms responsible for the increased liver tolerance of ischemia-reperfusion injury with special emphasis on vasodilatator mediators such as nitric oxide, on oxidative stress prevention, on protection against mitochondrial damage, and finally on induction of cytoprotective factors.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Fatty Liver / complications*
Humans
Organ Preservation Solutions*
Reperfusion Injury / etiology
Reperfusion Injury / prevention & control*

Substances

IGL-1 solution
Organ Preservation Solutions