Targeting aneuploidy for cancer therapy

Eusebio Manchado; Marcos Malumbres

doi:10.1016/j.cell.2011.01.037

Targeting aneuploidy for cancer therapy

Cell. 2011 Feb 18;144(4):465-6. doi: 10.1016/j.cell.2011.01.037.

Authors

Eusebio Manchado¹, Marcos Malumbres

Affiliation

¹ Cell Division and Cancer Group, Spanish National Cancer Research Centre, CNIO, Madrid, Spain.

PMID: 21335229
DOI: 10.1016/j.cell.2011.01.037

Abstract

Tumor cells frequently display an abnormal number of chromosomes, a phenomenon known as aneuploidy. Tang et al. (2011) now show that aneuploid cells are particularly sensitive to compounds that induce proteotoxic and energy stress. Could this vulnerability lead to new cancer therapies?

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