Targeting aneuploidy for cancer therapy

Cell. 2011 Feb 18;144(4):465-6. doi: 10.1016/j.cell.2011.01.037.


Tumor cells frequently display an abnormal number of chromosomes, a phenomenon known as aneuploidy. Tang et al. (2011) now show that aneuploid cells are particularly sensitive to compounds that induce proteotoxic and energy stress. Could this vulnerability lead to new cancer therapies?

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