Chemically targeting the emergent properties of a chaperone complex

Joseph C Genereux; R Luke Wiseman

doi:10.1016/j.chembiol.2011.02.002

Chemically targeting the emergent properties of a chaperone complex

Chem Biol. 2011 Feb 25;18(2):144-5. doi: 10.1016/j.chembiol.2011.02.002.

Authors

Joseph C Genereux¹, R Luke Wiseman

Affiliation

¹ Department of Molecular and Experimental Medicine and Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA.

PMID: 21338912
DOI: 10.1016/j.chembiol.2011.02.002

Abstract

In this issue, Chang et al. (2011) report a small molecule screen against the reconstituted DnaK-DnaJ-GrpE chaperone cycle. Through this approach, they identified myricetin as an inhibitor of DnaJ-stimulated DnaK ATPase activity, indicating the potential for their screening approach to identify modulators of emergent properties of protein complexes.

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