Cytotoxic T cells - stroma interactions

Bull Cancer. 2011 Feb;98(2):E19-24. doi: 10.1684/bdc.2010.1295.

Abstract

The tumor microenvironment is a complex system playing an important role in tumor development and progression. Besides tumor cells, the tumor microenvironment harbours a variety of host-derived cells, such as endothelial cells, fibroblasts, innate and adaptive immune cells, as well as extracellular matrix (ECM) fibers, cytokines, and other mediators. This review discusses the potential role of hypoxia and endothelial cells within tumor microenvironment and emphasizes their interaction with antigen specific killer cells.

Publication types

  • Review

MeSH terms

  • Antigen Presentation / physiology
  • Cell Communication / immunology
  • Cell Communication / physiology*
  • Cell Hypoxia / immunology
  • Cell Hypoxia / physiology*
  • Disease Progression
  • Endothelial Cells / immunology
  • Endothelial Cells / physiology*
  • Hypoxia-Inducible Factor 1, alpha Subunit / physiology*
  • Killer Cells, Natural / immunology
  • Killer Cells, Natural / physiology
  • Melanoma / immunology
  • Neoplasm Proteins / physiology*
  • STAT3 Transcription Factor / physiology
  • T-Lymphocytes, Cytotoxic / immunology
  • T-Lymphocytes, Cytotoxic / physiology*
  • Tumor Microenvironment / immunology
  • Tumor Microenvironment / physiology*
  • Vascular Endothelial Growth Factor A / physiology

Substances

  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Neoplasm Proteins
  • STAT3 Transcription Factor
  • STAT3 protein, human
  • Vascular Endothelial Growth Factor A