The impact of environmental exposure to perfluorinated compounds on oocyte fertilization capacity

J Assist Reprod Genet. 2011 May;28(5):415-8. doi: 10.1007/s10815-011-9548-2. Epub 2011 Feb 23.

Abstract

In an attempt to assess the effect of perfluorinated compounds (PFC) on oocytes quality and fertilization rate, we studied follicular fluid (FF) PFC levels in 18 patients undergoing IVF-ET cycles. A significant correlation (R = 0.75; P < 0.001) was observed between FF PFC levels and fertilization rate. Moreover, patients with FF PFC contamination had significantly lower fertilization rate (p < 0.02) and number of embryos transferred (p < 0.02), compared to the PFC negative group.

MeSH terms

  • Adult
  • Environmental Pollutants / analysis
  • Environmental Pollutants / toxicity*
  • Female
  • Fertilization in Vitro
  • Fluorocarbons / analysis
  • Fluorocarbons / toxicity*
  • Follicular Fluid / chemistry*
  • Humans
  • Infertility, Female / etiology
  • Oocytes / cytology
  • Oocytes / drug effects
  • Oocytes / physiology*
  • Pilot Projects

Substances

  • Environmental Pollutants
  • Fluorocarbons