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Review
. 2011 Mar;11(3):161-76.
doi: 10.1038/nrc3025.

Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins

Paula Martínez  1 , María A Blasco
Affiliations
Review

Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins

Paula Martínez et al. Nat Rev Cancer. 2011 Mar.

Abstract

Mammalian telomeres are formed by tandem repeats of the TTAGGG sequence, which are progressively lost with each round of cell division. Telomere protection requires a minimal length of TTAGGG repeats to allow the binding of shelterin, which prevents the activation of a DNA damage response (DDR) at chromosome ends. Telomere elongation is carried out by telomerase. Telomerase can also act as a transcriptional modulator of the Wnt-β-catenin signalling pathway and has RNA-dependent RNA polymerase activity. Dysfunctional telomeres can lead to either cancer or ageing pathologies depending on the integrity of the DDR. This Review discusses the role of telomeric proteins in cancer and ageing through modulating telomere length and protection, as well as regulating gene expression by binding to non-telomeric sites.

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References

    1. J Mol Biol. 2001 Sep 7;312(1):167-75 - PubMed
    1. Aging Cell. 2010 Oct;9(5):653-66 - PubMed
    1. Nature. 2003 Jun 26;423(6943):1013-8 - PubMed
    1. Curr Opin Plant Biol. 2003 Oct;6(5):430-40 - PubMed
    1. J Biol Chem. 2002 Feb 15;277(7):4778-81 - PubMed

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