Gammaherpesviruses entry and early events during infection

In: Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Cambridge: Cambridge University Press; 2007. Chapter 23.


The two human gammaherpesviruses, Epstein–Barr virus (EBV), a gamma 1 lymphocryptovirus and Kaposi’s sarcoma associated virus (KSHV), a gamma 2 rhadinovirus, have many features in common. They share an architecture that is typical of all members of the herpesvirus family, they share an ability to establish latency in lymphocytes, and they are both initiators or potentiators of human tumors. For the virologist some of the challenges they present are the same, in particular the relative dearth of fully permissive, easily manipulated cell culture systems for study. In this respect the many years of work on EBV provided an initial roadmap to accelerate study of KSHV. However, the strategies that the viruses use for cell infection and replication provide not only interesting reflections of common ancestry, but also interesting contrasts in adaptation to unique cellular niches in their human hosts.

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