Functional Specialization of interleukin-17 Family Members

Immunity. 2011 Feb 25;34(2):149-62. doi: 10.1016/j.immuni.2011.02.012.

Abstract

Interleukin-17A (IL-17A) is the signature cytokine of the recently identified T helper 17 (Th17) cell subset. IL-17 has six family members (IL-17A to IL-17F). Although IL-17A and IL-17F share the highest amino acid sequence homology, they perform distinct functions; IL-17A is involved in the development of autoimmunity, inflammation, and tumors, and also plays important roles in the host defenses against bacterial and fungal infections, whereas IL-17F is mainly involved in mucosal host defense mechanisms. IL-17E (IL-25) is an amplifier of Th2 immune responses. The functions of IL-17B, IL-17C, and IL-17D remain largely elusive. In this review, we describe the identified functions of each IL-17 family member and discuss the potential of these molecules as therapeutic targets.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoimmunity / immunology
  • Bacterial Infections / immunology
  • Humans
  • Immunity, Mucosal / immunology
  • Inflammation / immunology
  • Interleukin-17 / biosynthesis
  • Interleukin-17 / chemistry
  • Interleukin-17 / genetics
  • Interleukin-17 / immunology
  • Interleukin-17 / physiology*
  • Mice
  • Mice, Knockout
  • Multigene Family
  • Mycoses / immunology
  • Neoplasms / immunology
  • Receptors, Interleukin-17 / chemistry
  • Receptors, Interleukin-17 / deficiency
  • Receptors, Interleukin-17 / physiology
  • Sequence Homology, Amino Acid
  • Signal Transduction
  • Th17 Cells / immunology*
  • Th17 Cells / metabolism
  • Th2 Cells / immunology

Substances

  • Interleukin-17
  • Receptors, Interleukin-17