Microbial manipulation of receptor crosstalk in innate immunity

Nat Rev Immunol. 2011 Mar;11(3):187-200. doi: 10.1038/nri2918.


In the arms race of host-microbe co-evolution, successful microbial pathogens have evolved ingenious ways to evade host immune responses. In this Review, we focus on 'crosstalk manipulation' - the microbial strategies that instigate, subvert or disrupt the molecular signalling crosstalk between receptors of the innate immune system. This proactive interference undermines host defences and contributes to microbial adaptive fitness and persistent infections. Understanding how pathogens exploit host receptor crosstalk mechanisms and infiltrate the host signalling network is essential for developing interventions to redirect the host response and achieve protective immunity.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Amino Acid Motifs
  • Animals
  • Bacteria / immunology
  • Candida albicans / immunology
  • Host-Pathogen Interactions / immunology*
  • Humans
  • Immunity, Innate*
  • Mice
  • Models, Immunological
  • Molecular Mimicry
  • Receptor Cross-Talk / immunology*
  • Receptors, Pattern Recognition / antagonists & inhibitors
  • Receptors, Pattern Recognition / immunology*
  • Signal Transduction / immunology
  • Toll-Like Receptors / antagonists & inhibitors
  • Viruses / immunology


  • Receptors, Pattern Recognition
  • Toll-Like Receptors