Aging-related alterations in the extracellular matrix modulate the microenvironment and influence tumor progression

Int J Cancer. 2010 Dec 15;127(12):2739-48. doi: 10.1002/ijc.25615. Epub 2010 Oct 8.


Age is the greatest risk factor for the development of epithelial cancers. In this minireview, we will examine key extracellular matrix and matricellular components, their changes with aging, and discuss how these alterations might influence the subsequent progression of cancer in the aged host. Because of the tight correlation between advanced age and the prevalence of prostate cancer, we will use prostate cancer as the model throughout this minireview.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Aging / physiology*
  • Disease Progression
  • Extracellular Matrix / metabolism*
  • Extracellular Space / physiology*
  • Humans
  • Neoplasms / metabolism
  • Neoplasms / physiopathology*
  • Tumor Microenvironment / physiology*