Abstract
G3BP (Ras-GTPase-activating protein SH3 domain binding protein), a protein which binds to RasGAP SH3 domain, belongs to RNA-binding protein family, implicating in the downstream of Ras signaling. G3BP harbors the activities of endoribonuclease and DNA helicase, and can induce stress granules formation. G3BP plays a general role in the signal pathways of cell proliferation, differentiation, apoptosis and RNA metabolism. It has been shown to be over-expressed in a number of human malignancies and has a close relationship with tumor invasion and metastasis. Given that it has been implicated in several pathways that are known to be involved in cancer biology, G3BP may provide a new target for cancer therapy.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Carrier Proteins / genetics
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Carrier Proteins / metabolism*
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DNA Helicases
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Drug Delivery Systems*
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GTPase-Activating Proteins / therapeutic use
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Humans
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Molecular Sequence Data
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Neoplasms / drug therapy
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Neoplasms / metabolism*
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Neoplasms / pathology
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Peptide Fragments / therapeutic use
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Phosphorylation
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Poly-ADP-Ribose Binding Proteins
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RNA Helicases
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RNA Recognition Motif Proteins
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Signal Transduction*
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ras GTPase-Activating Proteins / metabolism
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src Homology Domains / genetics
Substances
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Carrier Proteins
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GTPase-Activating Proteins
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Peptide Fragments
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Poly-ADP-Ribose Binding Proteins
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RNA Recognition Motif Proteins
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TAT-RasGAP(317-326)
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ras GTPase-Activating Proteins
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DNA Helicases
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G3BP1 protein, human
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G3bp1 protein, mouse
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RNA Helicases