P-type ATPases

Annu Rev Biophys. 2011:40:243-66. doi: 10.1146/annurev.biophys.093008.131331.


P-type ATPases form a large superfamily of cation and lipid pumps. They are remarkably simple with only a single catalytic subunit and carry out large domain motions during transport. The atomic structure of P-type ATPases in different conformations, together with ample mutagenesis evidence, has provided detailed insights into the pumping mechanism by these biological nanomachines. Phylogenetically, P-type ATPases are divided into five subfamilies, P1-P5. These subfamilies differ with respect to transported ligands and the way they are regulated.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphatases / chemistry*
  • Adenosine Triphosphatases / metabolism*
  • Binding Sites
  • Computer Simulation
  • Ion Channel Gating / physiology*
  • Lipid Metabolism / physiology*
  • Lipids / chemistry*
  • Models, Biological
  • Models, Chemical
  • Protein Binding
  • Protein Structure, Tertiary


  • Lipids
  • Adenosine Triphosphatases