Familial and disease specific abnormalities in the neural correlates of the Stroop Task in Bipolar Disorder

Neuroimage. 2011 Jun 1;56(3):1677-84. doi: 10.1016/j.neuroimage.2011.02.052. Epub 2011 Feb 22.


Patients with Bipolar Disorder (BD) perform poorly on tasks of selective attention and inhibitory control. Although similar behavioural deficits have been noted in their relatives, it is yet unclear whether they reflect dysfunction in the same neural circuits. We used functional magnetic resonance imaging and the Stroop Colour Word Task to compare task related neural activity between 39 euthymic BD patients, 39 of their first-degree relatives (25 with no Axis I disorders and 14 with Major Depressive Disorder) and 48 healthy controls. Compared to controls, all individuals with familial predisposition to BD, irrespective of diagnosis, showed similar reductions in neural responsiveness in regions involved in selective attention within the posterior and inferior parietal lobules. In contrast, hypoactivation within fronto-striatal regions, implicated in inhibitory control, was observed only in BD patients and MDD relatives. Although striatal deficits were comparable between BD patients and their MDD relatives, right ventrolateral prefrontal dysfunction was uniquely associated with BD. Our findings suggest that while reduced parietal engagement relates to genetic risk, fronto-striatal dysfunction reflects processes underpinning disease expression for mood disorders.

MeSH terms

  • Adult
  • Analysis of Variance
  • Attention / physiology
  • Bipolar Disorder / diagnosis
  • Bipolar Disorder / genetics*
  • Bipolar Disorder / psychology*
  • Brain / physiology
  • Cerebral Cortex / pathology
  • Cerebral Cortex / physiopathology
  • Depressive Disorder, Major / genetics
  • Depressive Disorder, Major / psychology
  • Diagnosis, Differential
  • Diagnostic and Statistical Manual of Mental Disorders
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging
  • Male
  • Psychomotor Performance / physiology
  • Reaction Time / physiology
  • Risk Assessment
  • Socioeconomic Factors
  • Stroop Test*