Rh(NHC)-catalyzed direct and selective arylation of quinolines at the 8-position

J Am Chem Soc. 2011 Mar 23;133(11):3780-3. doi: 10.1021/ja111670s. Epub 2011 Feb 28.


A new catalytic protocol for the regioselective direct arylation of quinoline derivatives at the 8-position has been developed. The reaction is catalyzed by a Rh(NHC) system, and the choice of the NHC ligand was most important for achieving high reactivity and selectivity.