Primary cardiac synovial sarcoma: a case report and literature review

Pathol Int. 2011 Mar;61(3):150-5. doi: 10.1111/j.1440-1827.2010.02631.x. Epub 2010 Dec 16.


Primary cardiac synovial sarcoma is a rare disease. A 51-year-old man visited our hospital with the chief complaint of palpitations and shortness of breath while exercising. Copious bloody pericardial effusion and a multicystic intrapericardial tumor were detected. A primary cardiac malignant tumor was suspected, an open-chest tumor resection was performed with the objectives of diagnosis and treatment. Histologically, the tumor cells were uniformly spindle-shaped with an ovoid or oval nucleus, they had proliferated in fascicular fashion. In addition myxoid degeneration, a hemangiopericytomatous vascular pattern and pseudorosette formation were seen in some areas of the tumor. Based on the histopathological and immunohistochemical findings and reverse transcription polymerase chain reaction detection of SS18-SSX1 fusion transcripts, a monophasic fibrous type synovial sarcoma was diagnosed. Postoperative radiation therapy was administered and there had been no recurrence 9 months after the surgery.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Actins / metabolism
  • Angiolipoma / diagnosis
  • Antigens, CD34 / metabolism
  • Biomarkers, Tumor / metabolism
  • Diagnosis, Differential
  • Disease-Free Survival
  • Heart Neoplasms / metabolism
  • Heart Neoplasms / pathology*
  • Heart Neoplasms / surgery
  • Humans
  • Lipoma / diagnosis
  • Male
  • Middle Aged
  • Pericytes / metabolism
  • Pericytes / pathology*
  • Radiotherapy, Adjuvant
  • Sarcoma, Synovial / metabolism
  • Sarcoma, Synovial / pathology*
  • Sarcoma, Synovial / surgery
  • Thigh


  • Actins
  • Antigens, CD34
  • Biomarkers, Tumor