Regulation of lipid homeostasis by the bifunctional SREBF2-miR33a locus

Cell Metab. 2011 Mar 2;13(3):241-7. doi: 10.1016/j.cmet.2011.02.004.


The sterol regulatory element-binding factor-2 (SREBF2) gene is a bifunctional locus encoding SREBP-2, a well-known transcriptional regulator of genes involved in cholesterol biosynthesis, and microRNA-33a, which has recently been shown to reduce expression of proteins involved in export of cholesterol and β-oxidation of fatty acids, thus adding an unexpected layer of complexity and fine-tuning to regulation of lipid homeostasis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cholesterol / metabolism
  • Fatty Acids / metabolism
  • Humans
  • Lipid Metabolism / genetics*
  • Mice
  • MicroRNAs / metabolism*
  • Sterol Regulatory Element Binding Protein 2 / genetics
  • Sterol Regulatory Element Binding Protein 2 / metabolism*


  • Fatty Acids
  • MicroRNAs
  • Sterol Regulatory Element Binding Protein 2
  • Cholesterol