Voltage-sensing phosphatase: its molecular relationship with PTEN

Physiology (Bethesda). 2011 Feb;26(1):6-13. doi: 10.1152/physiol.00035.2010.

Abstract

Voltage-sensing phosphoinositide phosphatase (VSP) contains voltage sensor and cytoplasmic phosphatase domains. A unique feature of this protein is that depolarization-induced motions of the voltage sensor activate PtdIns(3,4,5)P(3) and PtdIns(4,5)P(2) phosphatase activities. VSP exhibits remarkable structural similarities with PTEN, the phosphatase and tensin homolog deleted on chromosome 10. These similarities include the cytoplasmic phosphatase region, the phosphoinositide binding region, and the putative membrane interacting C2 domain.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Models, Molecular
  • PTEN Phosphohydrolase / chemistry*
  • PTEN Phosphohydrolase / metabolism
  • Phosphatidylinositol 4,5-Diphosphate / metabolism
  • Phosphatidylinositol Phosphates / metabolism
  • Phosphoric Monoester Hydrolases / chemistry*
  • Phosphoric Monoester Hydrolases / metabolism
  • Protein Structure, Tertiary

Substances

  • Phosphatidylinositol 4,5-Diphosphate
  • Phosphatidylinositol Phosphates
  • phosphatidylinositol 3,4,5-triphosphate
  • Phosphoric Monoester Hydrolases
  • PTEN Phosphohydrolase
  • PTEN protein, human