Regulated intramembrane proteolysis: signaling pathways and biological functions

Physiology (Bethesda). 2011 Feb;26(1):34-44. doi: 10.1152/physiol.00028.2010.


Intramembrane cleavage of transmembrane proteins is a fundamental cellular process. Several enzymes capable of releasing domains of integral membrane proteins have been described. Transmembrane protein proteolytic cleavage is regulated and involved not only in degrading membrane spanning segments but also in generating messengers that elicit biological responses. This review examines the role of the released functional protein domain in signaling mechanisms regulating an array of cellular and physiological processes.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Membrane / metabolism
  • Humans
  • Membrane Proteins / metabolism*
  • Peptide Hydrolases / metabolism*
  • Signal Transduction


  • Membrane Proteins
  • Peptide Hydrolases