Hematopoietic SCT for adult T-cell leukemia/lymphoma: a review

Bone Marrow Transplant. 2011 Aug;46(8):1039-44. doi: 10.1038/bmt.2011.27. Epub 2011 Feb 28.


Adult T-cell leukemia/lymphoma is a T-cell malignancy caused by the human T-cell lymphotropic virus type 1. The aggressive forms of the disease carry a poor prognosis with standard therapies. The role of high-dose treatment with blood and marrow transplantation has, therefore, been examined mainly by Japanese groups in the form of retrospective studies. In this study, we review the literature, discuss some of the challenges facing successful transplantation approaches and stress the need for more innovative studies including in the Western hemisphere.

Publication types

  • Review

MeSH terms

  • Adult
  • Aged
  • Female
  • Hematopoietic Stem Cell Transplantation / methods*
  • Humans
  • Leukemia-Lymphoma, Adult T-Cell / surgery*
  • Male
  • Middle Aged