Disturbed glucoregulatory response to food intake after moderate sleep restriction

Sleep. 2011 Mar 1;34(3):371-7. doi: 10.1093/sleep/34.3.371.


Study objectives: Epidemiological studies point to a strong association between short sleep duration and the development of diabetes. We examined the hypothesis that short-term sleep loss decreases glucose tolerance and insulin sensitivity and, if so, how these changes relate to hypothalamic-pituitary-adrenal (HPA) secretory activity and markers of subclinical inflammation.

Design: In a balanced, within-subject design, circulating glucose, insulin, C-peptide, glucagon, ACTH, cortisol, and IL-6 levels were closely monitored during a 15-h daytime period following 2 nights of restricted sleep (02:45-07:00) and 2 nights of regular sleep (bedtime 22:45-07:00), respectively.

Setting: Time-deprivation suite within a university medical center sleep laboratory.

Participants: 15 healthy, unmedicated normal-weight men.

Intervention: Sleep restriction.

Measurements and results: Pre-breakfast concentrations of blood parameters were unchanged following sleep manipulation (P > 0.30). However, insulin and glucose peak responses to breakfast intake at 08:00 were distinctly increased by sleep restriction in comparison to regular sleep (398.5 ± 57.4 vs. 284.3 ± 51.5 pmol/L and 6.8 ± 0.3 vs. 6.1 ± 0.3 mmol/L, respectively; all P < 0.02), while glucagon responses were blunted by sleep loss (P = 0.03). There were no differences in circulating ACTH, cortisol, and IL-6 concentrations between the 2 conditions (all P > 0.25).

Conclusions: Data indicate an impairment of glucose tolerance after 2 days of sleep restriction to ~4 h that appears to be primarily caused by a reduction in insulin sensitivity. Unchanged HPA secretory activity and IL-6 concentrations argue against a mediation of these effects by stress-related or inflammatory mechanisms.

Keywords: Sleep deprivation; glucagon; glucose tolerance; insulin resistance; insulin sensitivity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenocorticotropic Hormone / blood
  • Adult
  • Blood Glucose / analysis
  • C-Peptide / blood
  • Eating / physiology*
  • Glucagon / blood
  • Glucose / metabolism*
  • Glucose / physiology
  • Glucose Tolerance Test
  • Humans
  • Hydrocortisone / blood
  • Insulin / blood
  • Insulin / physiology
  • Interleukin-6 / blood
  • Male
  • Polysomnography
  • Sleep Deprivation / physiopathology*
  • Young Adult


  • Blood Glucose
  • C-Peptide
  • Insulin
  • Interleukin-6
  • Adrenocorticotropic Hormone
  • Glucagon
  • Glucose
  • Hydrocortisone