Sequential Two-Step Multienzyme Synthesis of Tumor-Associated Sialyl T-antigens and Derivatives

Org Biomol Chem. 2011 Apr 21;9(8):2784-9. doi: 10.1039/c0ob01269f. Epub 2011 Mar 1.

Abstract

A series of α2-3-sialylated β1-3-linked galactosides, including sialyl T-antigens, 3'-sialyl galacto-N-biose, 3'-sialyl lacto-N-biose, and their derivatives containing natural and non-natural sialic acid forms have been synthesized from simple monosaccharides using an efficient sequential two-step multienzyme approach.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Antigens, Neoplasm / chemistry*
  • Antigens, Neoplasm / metabolism
  • Bifidobacterium / enzymology*
  • Galactosides / chemistry
  • Galactosyltransferases / metabolism*
  • Molecular Structure
  • N-Acetylneuraminic Acid / chemistry*
  • Pasteurella / enzymology*
  • Sialyltransferases / metabolism*

Substances

  • Antigens, Neoplasm
  • Galactosides
  • Galactosyltransferases
  • beta-1,3-galactosyl-N-acetylhexosamine phosphorylase
  • Sialyltransferases
  • N-Acetylneuraminic Acid