Neuroprotection by Spice-Derived Nutraceuticals: You Are What You Eat!

Mol Neurobiol. 2011 Oct;44(2):142-59. doi: 10.1007/s12035-011-8168-2. Epub 2011 Mar 1.

Abstract

Numerous lines of evidence indicate that chronic inflammation plays a major role in the development of various neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, brain tumor, and meningitis. Why these diseases are more common among people from some countries than others is not fully understood, but lifestyle factors have been linked to the development of neurodegenerative diseases. For example, the incidence of certain neurodegenerative diseases among people living in the Asian subcontinent, where people regularly consume spices, is much lower than in countries of the western world. Extensive research over the last 10 years has indicated that nutraceuticals derived from such spices as turmeric, red pepper, black pepper, licorice, clove, ginger, garlic, coriander, and cinnamon target inflammatory pathways, thereby may prevent neurodegenerative diseases. How these nutraceuticals modulate various pathways and how they exert neuroprotection are the focus of this review.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain Neoplasms / drug therapy
  • Clinical Trials as Topic
  • Diet
  • Dietary Supplements*
  • Humans
  • Inflammation / complications
  • Inflammation / prevention & control*
  • Molecular Structure
  • Neurodegenerative Diseases / etiology
  • Neurodegenerative Diseases / prevention & control*
  • Neuroprotective Agents / therapeutic use*
  • Plant Extracts / chemistry
  • Plant Extracts / therapeutic use
  • Spices*

Substances

  • Neuroprotective Agents
  • Plant Extracts