Recently it has been observed increasing number of drugged drivers in Wielkopolska region. In the period from 2006 to 2009 a total number of 2473 blood samples collected from drivers (2141 from alive suspects and 332 from deceased) and examined for psychoactive agents in the Department of Forensic Medicine Poznan University of Medical Sciences. Positive results were obtained in 68.8% and 22.3% of blood samples taken from living men and women respectively. In the group of deceased 7.3% (male) and 8.4% (female) were found positive. The most frequently detected substance were cannabinoids - 57.8%, then amphetamines and its analogues 18.8%, benzodiazepines 5.8%, opiates 3.4% and cocaine benzoiloecgonine 0.9%. In 13.0% concomitant use of amphetamine and cannabinoids were reported.