Inflammation and prevention of epileptogenesis

Neurosci Lett. 2011 Jun 27;497(3):223-30. doi: 10.1016/j.neulet.2011.02.040. Epub 2011 Feb 26.


CNS injuries such as trauma, stroke, viral infection, febrile seizures, status epilepticus occurring either in infancy or during a lifetime are considered common risk factors for developing epilepsy. Long term CNS inflammation develops rapidly after these events, suggesting that a pro-inflammatory state in the brain might play a role in the development of the epileptic process. This hypothesis is corroborated by two main lines of evidence: (1) the upregulation of pro-inflammatory signals during epileptogenesis in brain areas of seizure onset/generalization; (2) pharmacological targeting of specific pro-inflammatory pathways after status epilepticus or in kindling shows antiepileptogenic effects. The mechanisms by which pro-inflammatory molecules might favor the establishment of chronic neuronal network hyperexcitability involve both rapid, non-transcriptional effects on glutamate and GABA receptors, and transcriptional activation of genes involved in synaptic plasticity. This emerging evidence predicts that pharmacological interventions targeting brain inflammation might provide a key to new antiepileptic drug design.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anticonvulsants / administration & dosage*
  • Brain / drug effects
  • Brain / metabolism*
  • Encephalitis / complications
  • Encephalitis / metabolism*
  • Encephalitis / prevention & control*
  • Epilepsy / complications
  • Epilepsy / metabolism*
  • Epilepsy / prevention & control*
  • Humans


  • Anticonvulsants