Prevalence of primary Sjögren's syndrome in patients with multiple sclerosis

Ann Neurol. 1990 May;27(5):582-4. doi: 10.1002/ana.410270522.


Sixty-four consecutive patients with clinically or laboratory-supported definite multiple sclerosis (MS) were evaluated prospectively for evidence of primary Sjögren's syndrome (SS). This diagnosis was established when a patient had objective keratoconjunctivitis sicca, xerostomia, or both together with positive labial salivary gland biopsy. We found 2 patients (3.1%) with clinical evidence of primary SS. Whether this association is fortuitous or whether there is pathogenetic linkage between MS and primary SS remains to be established.

MeSH terms

  • Adult
  • Female
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis / complications*
  • Sjogren's Syndrome / complications*
  • Sjogren's Syndrome / diagnosis