Cerebral venous thrombosis in a Mexican multicenter registry of acute cerebrovascular disease: the RENAMEVASC study

J Stroke Cerebrovasc Dis. 2012 Jul;21(5):395-400. doi: 10.1016/j.jstrokecerebrovasdis.2011.01.001. Epub 2011 Mar 2.


Background: Cerebral venous thrombosis (CVT) is a rare form of cerebrovascular disease that is usually not mentioned in multicenter registries on all-type acute stroke. We aimed to describe the experience on hospitalized patients with CVT in a Mexican multicenter registry on acute cerebrovascular disease.

Methods: CVT patients were selected from the RENAMEVASC registry, which was conducted between 2002 and 2004 in 25 Mexican hospitals. Risk factors, neuroimaging, and 30-day outcome as assessed by the modified Rankin scale (mRS) were analyzed.

Results: Among 2000 all-type acute stroke patients, 59 (3%; 95% CI, 2.3-3.8%) had CVT (50 women; female:male ratio, 5:1; median age, 31 years). Puerperium (42%), contraceptive use (18%), and pregnancy (12%) were the main risk factors in women. In 67% of men, CVT was registered as idiopathic, but thrombophilia assessment was suboptimal. Longitudinal superior sinus was the most frequent thrombosis location (78%). Extensive (>5 cm) venous infarction occurred in 36% of patients. Only 81% of patients received anticoagulation since the acute phase, and 3% needed decompressive craniectomy. Mechanical ventilation (13.6%), pneumonia (10.2%) and systemic thromboembolism (8.5%) were the main in-hospital complications. The 30-day case fatality rate was 3% (2 patients; 95% CI, 0.23-12.2%). In a Cox proportional hazards model, only age <40 years was associated with a mRS score of 0 to 2 (functional independence; rate ratio, 3.46; 95% CI, 1.34-8.92).

Conclusions: The relative frequency of CVT and the associated in-hospital complications were higher than in other registries. Thrombophilia assessment and acute treatment was suboptimal. Young age is the main determinant of a good short-term outcome.

Publication types

  • Multicenter Study

MeSH terms

  • Adult
  • Age Factors
  • Cerebral Veins*
  • Cerebrovascular Disorders
  • Female
  • Hospitalization
  • Humans
  • Kaplan-Meier Estimate
  • Length of Stay
  • Male
  • Mexico / epidemiology
  • Neuroimaging
  • Pregnancy
  • Pregnancy Complications, Cardiovascular
  • Prognosis
  • Proportional Hazards Models
  • Prospective Studies
  • Registries
  • Risk Factors
  • Stroke / complications*
  • Venous Thrombosis / complications*
  • Venous Thrombosis / epidemiology
  • Young Adult