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Controlled Clinical Trial
, 93 (5), 963-7

Core Body Temperature in Obesity

Affiliations
Controlled Clinical Trial

Core Body Temperature in Obesity

Marc J Heikens et al. Am J Clin Nutr.

Abstract

Background: A lower core body temperature set point has been suggested to be a factor that could potentially predispose humans to develop obesity.

Objective: We tested the hypothesis that obese individuals have lower core temperatures than those in normal-weight individuals.

Design: In study 1, nonobese [body mass index (BMI; in kg/m(2)) <30] and obese (BMI ≥30) adults swallowed wireless core temperature-sensing capsules, and we measured core temperatures continuously for 24 h. In study 2, normal-weight (BMI of 18-25) and obese subjects swallowed temperature-sensing capsules to measure core temperatures continuously for ≥48 h and kept activity logs. We constructed daily, 24-h core temperature profiles for analysis.

Results: Mean (±SE) daily core body temperature did not differ significantly between the 35 nonobese and 46 obese subjects (36.92 ± 0.03°C compared with 36.89 ± 0.03°C; P = 0.44). Core temperature 24-h profiles did not differ significantly between 11 normal-weight and 19 obese subjects (P = 0.274). Women had a mean core body temperature ≈0.23°C greater than that of men (36.99 ± 0.03°C compared with 36.76 ± 0.03°C; P < 0.0001).

Conclusions: Obesity is not generally associated with a reduced core body temperature. It may be necessary to study individuals with function-altering mutations in core temperature-regulating genes to determine whether differences in the core body temperature set point affect the regulation of human body weight. These trials were registered at clinicaltrials.gov as NCT00428987 and NCT00266500.

Figures

FIGURE 1
FIGURE 1
Mean daily core temperatures. A: Nonobese compared with obese subjects. No significant differences in the core body temperature between nonobese and obese individuals were detected. B: Male compared with female subjects. Women had an ≈0.23°C higher mean core temperature than that in men. The analysis was conducted by using Student's t test.
FIGURE 2
FIGURE 2
Twenty-four-hour core temperature profiles. A: Normal-weight compared with obese subjects. Obesity status was not a significant predictor of core temperature. B: Male compared with female subjects. Women had, on average, a 0.27°C higher core temperature than that in men throughout the day. The analysis was conducted by using ANCOVA with repeated measures.

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