A systematic investigation of confirmed autoimmune loci in early-onset psoriasis reveals an association with IL2/IL21

Br J Dermatol. 2011 Mar;164(3):660-4. doi: 10.1111/j.1365-2133.2011.10237.x.


Background: Many autoimmune diseases share common susceptibility loci suggesting similar underlying cellular mechanisms involved in disease expression.

Objectives: The purpose of this investigation was to study 21 genetic variants in 14 genes that are confirmed autoimmune loci in a cohort of patients with early-onset psoriasis.

Methods: Patients with early-onset psoriasis (n = 750) and controls (n = 3531) were genotyped using the Sequenom(®) MassArray™ iPLEX Gold platform.

Results: We found strong evidence of association with two variants in the IL2/IL21 (rs6822844, genotypic P = 3·3 × 10(-4) ; rs2069778, genotypic P = 7·86 × 10(-4)) region.

Conclusions: The findings, although requiring replication, suggest that IL2/IL21 may play a key role in the pathogenesis of psoriasis as well as in other diverse autoimmune diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age of Onset
  • Cohort Studies
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Interleukin-2 / genetics*
  • Interleukins / genetics*
  • Male
  • Polymorphism, Single Nucleotide / genetics
  • Psoriasis / genetics*
  • Psoriasis / immunology
  • Young Adult


  • Interleukin-2
  • Interleukins
  • interleukin-21