Uncovering a tumor suppressor for triple-negative breast cancers

Cell. 2011 Mar 4;144(5):638-40. doi: 10.1016/j.cell.2011.02.030.


"Triple-negative" breast cancers are aggressive malignancies that respond poorly to treatments. Now Sun et al. (2011) find that the activity of the protein tyrosine phosphatase PTPN12 is lost in a large percentage of this breast cancer subtype, offering molecular drivers and possible therapeutic targets for this heterogeneous and intractable cancer.

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