Metabolic products of microorganisms. 255. Nikkomycins Wz and Wx, new chitin synthetase inhibitors from Streptomyces tendae

J Antibiot (Tokyo). 1990 Jan;43(1):43-8. doi: 10.7164/antibiotics.43.43.

Abstract

Two new dipeptidyl nikkomycins of the Z and X type were isolated from the culture broth of Streptomyces tendae TU 901/395-11/32 and characterized. They show a variation in the amino acid moiety of the molecule. Nikkomycin Wz is composed of L-tyrosine and 5-amino-5-deoxy-D-allo-furanuronic acid N-glycosidally bound to uracil, whereas nikkomycin Wx is composed of L-tyrosine and 5-amino-5-deoxy-D-allo-furanuronic acid N-glycosidally bound to 4-formyl-4-imidazolin-2-one. The new nikkomycins are good inhibitors of chitin synthetase from Coprinus cinereus but they did not inhibit growth of fungi and yeasts.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminoglycosides*
  • Anti-Bacterial Agents / analysis
  • Anti-Bacterial Agents / biosynthesis
  • Anti-Bacterial Agents / pharmacology*
  • Antifungal Agents / analysis
  • Antifungal Agents / biosynthesis
  • Antifungal Agents / pharmacology*
  • Chitin Synthase / antagonists & inhibitors*
  • Chromatography, High Pressure Liquid
  • Fermentation
  • Glucosyltransferases / antagonists & inhibitors*
  • Magnetic Resonance Spectroscopy
  • Spectrophotometry, Ultraviolet
  • Streptomyces / metabolism*

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • Antifungal Agents
  • nikkomycin
  • Glucosyltransferases
  • Chitin Synthase