Stratifying the patient at risk from coronary disease: new insights from the Framingham Heart Study

Am Heart J. 1990 Mar;119(3 Pt 2):712-7; discussion 717. doi: 10.1016/s0002-8703(05)80050-x.


Although cardiovascular disease remains the leading cause of death in the United States, cardiovascular disease mortality has decreased steadily during the past 2 decades. This trend is largely attributable to improved detection and management of cardiovascular risk factors, in which the Framingham Heart Study has played a major role. This article examines some of the risk factors associated with coronary heart disease, notably, advancing age, hypertension, left ventricular hypertrophy, smoking, elevated serum cholesterol, and reduced high-density lipoprotein, all of which have been investigated by the Framingham Heart Study. In addition, new data are presented from a multidimensional model of coronary heart disease. This is a novel approach that takes into account the interactions of multiple risk factors and their contribution to overall coronary heart disease risk.

MeSH terms

  • Adult
  • Age Factors
  • Algorithms
  • Cardiomegaly / complications
  • Cholesterol / blood
  • Coronary Disease / blood
  • Coronary Disease / complications
  • Coronary Disease / epidemiology*
  • Female
  • Humans
  • Hypertension / complications
  • Incidence
  • Male
  • Massachusetts / epidemiology
  • Middle Aged
  • Multivariate Analysis
  • Regression Analysis
  • Risk
  • Risk Factors
  • Sex Factors
  • Smoking / adverse effects


  • Cholesterol