A total of 7488 7th-12th grade African-American students completed a survey assessing factors associated with recent alcohol use. Results indicated that 13.6% used alcohol in the past month. A series of odds ratios revealed that making good grades, participating in school activities, attending church, and having parents/teachers talk about the dangers of alcohol and set/enforce rules regarding alcohol were associated with decreased recent use. Participating in risky behaviors such as getting into trouble, skipping school, and having friends who use alcohol and other drugs was directly related to recent use. Prevention specialists should encourage parents/teachers to engage youth in family, school, and community activities to deter alcohol use. Results may assist youth health professionals in developing prevention programs aimed at African-American youth.