Exercise is medicine in cystic fibrosis

Exerc Sport Sci Rev. 2011 Jul;39(3):155-60. doi: 10.1097/JES.0b013e3182172a5a.


Exercise activates adrenergic and purinergic pathways that regulate activity of ion channels on airway epithelia cells and sweat glands. Therefore, we hypothesize that exercise is not only an important therapy for cystic fibrosis (CF) patients by facilitating systemic improvements but, more importantly, that exercise can improve the pathophysiological ion dysregulation at a cellular level, thereby enhancing quality of life in CF.

Publication types

  • Review

MeSH terms

  • Body Temperature Regulation / physiology
  • Cystic Fibrosis / physiopathology
  • Cystic Fibrosis / therapy*
  • Cystic Fibrosis Transmembrane Conductance Regulator / physiology
  • Exercise / physiology*
  • Exercise Therapy*
  • Female
  • Humans
  • Lung / physiopathology
  • Sweat Glands / physiology
  • Water-Electrolyte Balance / physiology


  • Cystic Fibrosis Transmembrane Conductance Regulator