Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Mar;17(3):297-303.
doi: 10.1038/nm.2323.

Cancer Genomics: From Discovery Science to Personalized Medicine

Affiliations

Cancer Genomics: From Discovery Science to Personalized Medicine

Lynda Chin et al. Nat Med. .

Abstract

Recent advances in genome technologies and the ensuing outpouring of genomic information related to cancer have accelerated the convergence of discovery science and clinical medicine. Successful examples of translating cancer genomics into therapeutics and diagnostics reinforce its potential to make possible personalized cancer medicine. However, the bottlenecks along the path of converting a genome discovery into a tangible clinical endpoint are numerous and formidable. In this Perspective, we emphasize the importance of establishing the biological relevance of a cancer genomic discovery in realizing its clinical potential and discuss some of the major obstacles to moving from the bench to the bedside.

Similar articles

See all similar articles

Cited by 174 articles

See all "Cited by" articles

References

    1. Cancer Res. 2004 Nov 1;64(21):7678-81 - PubMed
    1. Drug Discov Today. 2010 Jul;15(13-14):517-30 - PubMed
    1. Science. 2010 Oct 8;330(6001):228-31 - PubMed
    1. Cancer Cell. 2005 Apr;7(4):387-97 - PubMed
    1. Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19893-7 - PubMed

LinkOut - more resources

Feedback