Modulation of NF-κB signalling by microbial pathogens

Nat Rev Microbiol. 2011 Apr;9(4):291-306. doi: 10.1038/nrmicro2539. Epub 2011 Mar 8.


The nuclear factor-κB (NF-κB) family of transcription factors plays a central part in the host response to infection by microbial pathogens, by orchestrating the innate and acquired host immune responses. The NF-κB proteins are activated by diverse signalling pathways that originate from many different cellular receptors and sensors. Many successful pathogens have acquired sophisticated mechanisms to regulate the NF-κB signalling pathways by deploying subversive proteins or hijacking the host signalling molecules. Here, we describe the mechanisms by which viruses and bacteria micromanage the host NF-κB signalling circuitry to favour the continued survival of the pathogen.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptive Immunity
  • Animals
  • Bacteria / genetics
  • Bacteria / metabolism*
  • Bacteria / pathogenicity
  • Bacterial Infections / immunology
  • Bacterial Infections / microbiology*
  • Immunity, Innate
  • Mice
  • NF-kappa B / metabolism*
  • Signal Transduction*
  • Virus Diseases / immunology
  • Virus Diseases / microbiology*
  • Viruses / immunology
  • Viruses / metabolism*
  • Viruses / pathogenicity


  • NF-kappa B