Microwave assisted synthesis of bridgehead alkenes

Org Lett. 2011 Apr 1;13(7):1781-3. doi: 10.1021/ol200244p. Epub 2011 Mar 8.

Abstract

A new, concise method to synthesize triene precursors for the type 2 intramolecular Diels-Alder reaction has been developed. Microwave irradiation of the trienes provides a convenient method for the synthesis of bridgehead alkenes. Higher yields, shorter reaction times, and lower reaction temperatures provide a general and efficient route to this interesting class of molecules.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Alkenes / chemical synthesis*
  • Microwaves*
  • Molecular Structure

Substances

  • Alkenes