Mutation of a gene that encodes a kinesin-like protein blocks nuclear division in A. nidulans

Cell. 1990 Mar 23;60(6):1019-27. doi: 10.1016/0092-8674(90)90350-n.

Abstract

In A. nidulans, the temperature-sensitive cell cycle mutation bimC4 causes an elevated mitotic index at restrictive temperature. Under restrictive conditions the mutation interferes with separation of the spindle pole bodies, causes abnormal spindle morphology, and prevents nuclear division. We have cloned and sequenced the wild-type bimC gene. The predicted protein product has homology to Drosophila kinesin heavy chain. We conclude that this kinesin-like protein has an important role in nuclear division in Aspergillus.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenosine Triphosphatases / genetics*
  • Amino Acid Sequence
  • Aspergillus nidulans / cytology
  • Aspergillus nidulans / genetics*
  • Base Sequence
  • Cell Nucleus / ultrastructure*
  • Fungal Proteins / genetics*
  • Genes, Fungal*
  • Kinesin
  • Macromolecular Substances
  • Mitosis
  • Mitotic Index
  • Molecular Sequence Data
  • Mutation*
  • Sequence Homology, Nucleic Acid

Substances

  • Fungal Proteins
  • Macromolecular Substances
  • Adenosine Triphosphatases
  • Kinesin

Associated data

  • GENBANK/M32075