Nocturia is one of the most bothersome symptoms of lower urinary tract and may be the leading symptom in medical examination. Nocturia has a special aspect of being of multifactorial etiology so an interdisciplinary approach for the diagnosis and treatment is obligatory. At present, nocturia is considered to be a new entity excluded from the symptoms of lower urinary tract and may be a consequence of serious disease. Diagnosis consists of non-invasive methods and the mainstay is the micturition diary. Treatment is based on desmopressin therapy and drugs influencing lower urinary tract in some cases.