HLA-C locus and genetic susceptibility to psoriatic arthritis in Romanian population

Tissue Antigens. 2011 Apr;77(4):325-8. doi: 10.1111/j.1399-0039.2010.01624.x.


We determined the distribution of human leukocyte antigen-C (HLA-C) allelic groups in a cohort of psoriatic arthritis (PsA) patients and a control population of Romanian ethnicity. A nominal association of HLA-C*06 with susceptibility to PsA was observed [P = 0.014, p(corr) > 0.05, odds ratio (OR) 2.1, 95% confidence interval (CI) 1.08-4.46]. When subanalyzing data according to PsA clinical phenotypes, association was noticed between HLA-C*06 and PsA with psoriasis onset before 40 years (p(corr) = 0.013, OR 3.7, 95% CI 1.58-9). This first report from Romania confirmed the association of HLA-C*06 with type I psoriasis in PsA patients. Other study findings, such as the relationship between HLA-C*06 and spondylitis or the protective effect of HLA-C*07 for the polyarthritis clinical phenotype of PsA, are of preliminary character and require verification.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age of Onset
  • Cohort Studies
  • Female
  • Genetic Predisposition to Disease*
  • HLA-C Antigens / genetics*
  • HLA-C Antigens / immunology
  • Humans
  • Male
  • Middle Aged
  • Psoriasis / epidemiology
  • Psoriasis / genetics*
  • Psoriasis / immunology
  • Romania / epidemiology


  • HLA-C Antigens