FDG PET/CT imaging in canine cancer patients

Vet Radiol Ultrasound. Mar-Apr 2011;52(2):201-6. doi: 10.1111/j.1740-8261.2010.01757.x. Epub 2010 Oct 26.

Abstract

2-Deoxy-2-[¹⁸F]fluoro-D-glucose positron emission tomography/computed tomography (FDG PET/CT) is becoming increasingly available as an imaging modality in veterinary medicine. The purpose of this study was to report semiquantitative standard uptake values (SUV) of malignant and nonmalignant tissues and organs in canine cancer patients. FDG PET/CT was performed in 14 dogs including, nine mesenchymal tumors, four carcinomas, and one incompletely excised mast cell tumor. A generally higher FDG uptake was observed in carcinomas relative to sarcomas. Maximum SUV of carcinomas ranged from 7.6 to 27.0, and for sarcomas from 2.0 to 10.6. The FDG SUV of several organs and tissues, including regional brain uptake is reported, to serve as a reference for future FDG PET studies in canine cancer patients. Several potential pitfalls have been recognized in interpretation of FDG PET images of human patients, a number of these were also observed in this study.

MeSH terms

  • Animals
  • Brain / diagnostic imaging
  • Dog Diseases / diagnostic imaging*
  • Dogs
  • Fluorodeoxyglucose F18*
  • Heart / diagnostic imaging
  • Kidney Cortex / diagnostic imaging
  • Liver / diagnostic imaging
  • Muscle, Skeletal / diagnostic imaging
  • Neoplasms / diagnostic imaging
  • Neoplasms / veterinary*
  • Positron-Emission Tomography / veterinary*
  • Reference Values
  • Spleen / diagnostic imaging
  • Submandibular Gland / diagnostic imaging
  • Tomography, X-Ray Computed / veterinary*

Substances

  • Fluorodeoxyglucose F18