Using causal diagrams to guide analysis in missing data problems

Stat Methods Med Res. 2012 Jun;21(3):243-56. doi: 10.1177/0962280210394469. Epub 2011 Mar 9.

Abstract

Estimating causal effects from incomplete data requires additional and inherently untestable assumptions regarding the mechanism giving rise to the missing data. We show that using causal diagrams to represent these additional assumptions both complements and clarifies some of the central issues in missing data theory, such as Rubin's classification of missingness mechanisms (as missing completely at random (MCAR), missing at random (MAR) or missing not at random (MNAR)) and the circumstances in which causal effects can be estimated without bias by analysing only the subjects with complete data. In doing so, we formally extend the back-door criterion of Pearl and others for use in incomplete data examples. These ideas are illustrated with an example drawn from an occupational cohort study of the effect of cosmic radiation on skin cancer incidence.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Causality*
  • Data Interpretation, Statistical*