Growth and siderophore production by Bordetella pertussis under iron-restricted conditions

FEMS Microbiol Lett. 1990 Jan 1;54(1-3):101-5. doi: 10.1016/0378-1097(90)90265-r.


It has been demonstrated that under iron-restricted conditions Bordetella pertussis can obtain iron from iron-saturated human transferrin. Direct contact between B. pertussis and transferrin was not required as B. pertussis was able to acquire iron from transferrin when they were separated by a dialysis membrane. Siderophore activity was detected in supernatants from iron-restricted cultures of B. pertussis, B. bronchiseptica and B. parapertussis. Siderophores were identified as hydroxamates and were produced by both virulent and avirulent strains of B. pertussis.

MeSH terms

  • Bordetella pertussis / drug effects
  • Bordetella pertussis / growth & development
  • Bordetella pertussis / metabolism*
  • Carrier Proteins / metabolism
  • Edetic Acid / pharmacology
  • Hydroxamic Acids / metabolism
  • Iron / metabolism*
  • Iron Chelating Agents / metabolism*
  • Iron-Binding Proteins
  • Siderophores
  • Transferrin / metabolism
  • Transferrin / pharmacology
  • Transferrin-Binding Proteins


  • Carrier Proteins
  • Hydroxamic Acids
  • Iron Chelating Agents
  • Iron-Binding Proteins
  • Siderophores
  • Transferrin
  • Transferrin-Binding Proteins
  • EDDA
  • Edetic Acid
  • Iron